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US 2022/0087562 A1Published application
Quantitative measurement of disruptions in the blood brain barrier
AssigneeNortheastern University
InventorsCraig Ferris, Ju Qiao, Praveen Kulkarni, Codi Gharagouzloo
Life of this patent
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Abstract
Disclosed are methods for determining blood brain barrier disruption in a subject in need thereof. The methods include administering intravascularly a contrast agent to the subject; performing quantitative ultra-short time-to-echo contrast-enhanced magnetic resonance imaging (QUTE-CE MRI) on a region of interest of the subject's brain; and determining presence of the contrast agent in brain parenchyma and/or cerebral spinal fluid within the region of interest.
Claims21
A method for determining blood brain barrier disruption, comprising:
- administering intravascularly a contrast agent to a subject in need thereof;
- performing quantitative ultra-short time-to-echo contrast-enhanced magnetic resonance imaging (QUTE-CE MRI) on a region of interest of the subject's brain;
- and determining presence of the contrast agent in brain parenchyma or cerebral spinal fluid within the region of interest.
Dependencies are inferred from the claim text.