Non-human animal models of sézary syndrome
AssigneesInserm (Institut National De La Sante Et De La Recherche Medicale), Universite De Paris, Assistance Publique-HôPitaux De Paris (Aphp)
InventorsAnne MARIE-CARDINE, Jean-Luc POYET, Justine HABAULT, Armand BENSUSSAN, Martine BAGOT
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Abstract
Sézary syndrome is a rare, aggressive, and leukemic form of cutaneous T-cell lymphoma (CTCL) characterized by erythroderma associated with generalized peripheral lymphadenopathy and circulating clonal malignant T cells called Sézary cells. Current animal models of Sézary syndrome are not satisfactory since no cutaneous symptoms or occurrence of metastases could be observed. Now the inventors developed a new non-human animal model that repeat the major cutaneous symptoms of the human disease. This model could be suitable for screening new drugs and biomarkers of the disease.
Claims15
A process of producing an animal model of Sézary syndrome comprising the steps of i) engrafting an amount of peripheral blood mononuclear cells (PBMC) obtained from a patient suffering from the disease in an immunodeficient non-human animal and ii) promoting the expansion and maintaining the survival of tumor cells by weekly administering to the animal an amount of IL-2 and IL-7.
A non-human animal model of Sézary syndrome obtainable by a process of producing an animal model, said process comprising the steps of i) engrafting an amount of peripheral blood mononuclear cells (PBMC) obtained from a patient suffering from the disease in an immunodeficient non-human animal and ii) promoting the expansion and maintaining the survival of tumor cells by weekly administering to the animal an amount of IL-2 and IL-7.
Dependencies are inferred from the claim text.