Prostaglandin E Synthase Inhibitors and Methods for Utilizing the Same

A compound of the formula:

• (a)
• or pharmaceutically acceptable salts thereof,
• wherein R1 is selected from the group consisting of H, an alkyl, an alkyl halide, an ether, and a carboxylic acid;
• wherein R2 is selected from the group consisting of H, a halide, an alkyne, and an aromatic;
• and
• wherein R3 is selected from the group consisting of H, a carboxyl, a carboxylic acid, and an alkyl;
• or
• (b)
• or pharmaceutically acceptable salts thereof;
• wherein R is selected from the group consisting of an aliphatic side chain and an alkyl;
• wherein X is selected from the group consisting of H, NO2, Br, and OMe;
• and
• wherein R′ and R″ are independently selected from the group consisting of CN, COOH, COOEt, CONH2, and NO2.