Ophthalmic Drug Compositions
AssigneeOxular Limited
InventorsRonald K. Yamamoto, Stanley R. Conston, Tien Nguyen
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Abstract
The present invention provides a composition for treatment of ophthalmic disease comprising a solid or semi-solid containing drug shaped as an elongated body for injection or delivery into tissue spaces of the eye. The composition may comprise a plurality of drug-containing particles and at least one excipient to form the drug particles into a flexible solid or a semisolid. The excipient comprises a substance that undergoes dissolution in the physiological conditions of the tissue space after injection to allow the microspheres to disperse and migrate in the tissue space. Formulations for the drug containing compositions, methods of fabrication and methods of use are also disclosed.
Claims37
1-90. (canceled)
A drug composition for delivery to the suprachoroidal space or supraciliary space comprising a flexible solid elongate body for injection into the suprachoroidal space or supraciliary space, wherein the flexible solid elongate body comprises:
- i) a plurality of spherical particles comprising a drug, and
- ii) at least one excipient that acts as a binder to form the spherical particles into the flexible solid,
- wherein said spherical particles comprise a biodegradable or bioerodable polymer that undergoes biodegradation or bioerosion in the suprachoroidal space or supraciliary space after injection, and
- wherein said binder comprises either i) a water soluble polymer or ii) a lipid or fatty acid that undergoes dissolution in the physiological conditions of the suprachoroidal space or supraciliary space after injection by absorption of fluid from the suprachoroidal space or supraciliary space due to the ionic environment or the temperature of the suprachoroidal space or supraciliary space to allow the spherical particles to disperse and migrate into the suprachoroidal space or supraciliary space.
Dependencies are inferred from the claim text.