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US 2022/0074922 A1Published application
Polymer microfilters, devices comprising the same, methods of manufacturing the same, and uses thereof
AssigneeCreatv MicroTech, Inc.
InventorsOlga Makarova, Cha-Mei Tang, Peixuan Zhu, Shuhong Li, Daniel Adams, Platte T. Amstutz
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Abstract
A microfilter having a hydrophilic surface and suited for size-based capture and analysis of cells, such as circulating cancer cells, from whole blood and other human fluids is disclosed. The filter material is photo-definable, allowing the formation of precision pores by UV lithography. Exemplary embodiments provide a device that combines a microfilter with 3D nanotopography in culture scaffolds that mimic the 3D in vivo environment to better facilitate growth of captured cells.
Claims15
A microfilter comprising:
- a first polymer layer formed from an epoxy-based photo-definable dry film, wherein the first polymer layer has flexibility to be disposed on a roll and unrolled;
- a plurality of first apertures each extending through the first polymer layer formed by exposing the first polymer layer to a UV light via an optical mask to obtain a selected shape of said apertures based on said optical mask, said first polymer layer forming at least a portion of said microfilter;
- and
- a surface on said first polymer layer modified to be hydrophilic,
- wherein said surface comprises bonding sites for reagents.
2 more elements
Dependencies are inferred from the claim text.