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US 2022/0073648 A1Published application
Influenza vaccines and methods of use thereof
OwnerStephen D. Gilliesinventor
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Abstract
The disclosure relates to anti-idiotypic antibodies and related influenza virus vaccines.
Claims21
An anti-idiotypic antibody comprising an idiotope mimicking an influenza virus antigen.
A vaccine composition comprising the anti-idiotypic antibody of any preceding claim and a pharmaceutically acceptable carrier.
20-41. (canceled)
A method of producing a vaccine for influenza virus comprising:
- providing a first antibody specific for an influenza virus antigen within a stalk region of hemagglutinin;
- and
- producing a second antibody against the first antibody;
- detecting binding of the first antibody to the influenza virus antigen within the stalk region of hemagglutinin in the presence and absence of the second antibody;
- immunizing an animal with the second antibody if the binding of the first antibody to the influenza virus antigen within the stalk region of hemagglutinin is decreased in the presence of the second antibody relative to in the absence of the second antibody;
- detecting binding of a serum antibody from the immunized animal to a influenza virus hemagglutinin;
- and
- selecting the second antibody as a component of the vaccine if the second antibody is an anti-idiotypic antibody comprising an idiotope mimicking the influenza virus antigen within the stalk region of hemagglutinin,
- wherein the second antibody is an anti-idiotypic antibody comprising an idiotope mimicking the influenza virus antigen within the stalk region of hemagglutinin if the serum antibody binds to the influenza virus hemagglutinin.
6 more elements
Dependencies are inferred from the claim text.