Amyloid precursor protein as a diagnostic marker for biliary atresia
AssigneeVersitech Limited
InventorsChi Hang LUI, Rosana Ottakandathil Babu, Paul Kwong Hang Tam
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Abstract
Provided are novel diagnostic and prognostic methods for biliary atresia using amyloid precursor protein.
Claims23
A method for diagnosing biliary atresia (BA) or assessing risk of developing BA in an infant, comprising:
- determining expression level of amyloid precursor protein (APP) in a liver sample taken from the infant;
- (ii) detecting an increase in the APP expression level from step (i) when compared with a standard control value;
- and
- (iii) determining the infant as having BA or having an increased risk of developing BA.
A method for assessing likelihood of ineffective Kasai procedure in an infant who has BA and has undergone Kasai procedure, comprising:
- (i) determining expression level of amyloid precursor protein (APP) in a liver sample taken from the infant;
- (ii) detecting an increase in the APP expression level from step (i) when compared with a standard control value;
- and
- (iii) determining the Kasai procedure as likely ineffective.
A kit for diagnosing BA or assessing risk of developing BA in an infant, comprising a first container containing a reagent for detecting expression level of APP and a second container containing a composition having a standard control level of APP expression.
Dependencies are inferred from the claim text.