Hiv serosignatures for cross-sectional incidence estimation
AssigneeThe Johns Hopkins University
InventorsSusan H. Eshleman, Oliver Laeyendecker, Harry B. Larman, Kai Kammers
Life of this patent
Estimating the term…
Abstract
Described are methods for estimating the cross-sectional incidence or duration of infection of a virus. Method steps include obtaining a biological sample with antibodies from a subject having a viral infection. The biological sample is mixed with two or more epitopes or peptides from the proteins of a vims responsible for the viral infection. The amount of antibody binding to the epitopes or peptides is quantified and the cross-sectional incidence or duration of infection of a virus is estimated.
Claims16
A method of identifying the cross-sectional incidence or duration of infection for a virus comprising the steps of:
- obtaining a biological sample comprising antibodies from a subject who has one or more viral infections;
- mixing the biological sample with a plurality of epitopes or peptides of the proteins from one or more viruses responsible for the one or more viral infections;
- quantifying the amount of antibody binding to the plurality of epitopes or peptides of the proteins from the one or more viruses;
- and
- estimating the cross-sectional incidence or duration of infection for the one or more viruses.
Dependencies are inferred from the claim text.