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US 2022/0065768 A1Published application
Blood separation and analysis device and methods
Assignee1866402 Ontario Limited
InventorJeffrey Sutton
Life of this patent
Estimating the term…
Abstract
There is provided a device and method for separation of blood, including sedimentation of plasma using PVA. The device comprises an inner container enclosed in an outer container, wherein upon alignment of respective openings, allows sample to exit from the inner container into a reaction structure. The reaction structure comprises one or more layers, each with one or more portions each containing concentrations of one or more chemicals.
Claims23
A method comprising:
- obtaining, from an image sensor, image data representing a fluid sample diluted and reacted with reagents, the image data comprising image elements identifying instances of light intensity;
- correlating each of the image elements with instances of one or more reagent reactions;
- estimating a final concentration of a dilution analyte in the fluid sample based on the correlating;
- determining a dilution factor of the fluid sample by comparing the final concentration of the dilution analyte with a known initial concentration of dilution first analyte;
- determining a relative volume of the fluid;
- and
- estimating a presence of a test analyte in the fluid sample based at least in part on the correlating, the dilution factor and the relative volume.
4 more elements
9-12. (canceled)
A mobile device comprising:
- an image sensor;
- a processor;
- and
- a memory storing processor executable instructions that when executed cause said processor to:
- obtain, from the image sensor, image data representing plasma separated from whole blood, diluted, and reacted with reagents, the image data comprising image elements identifying instances of light intensity;
- correlate each of the image elements with instances of one or more reagent reactions to generate a correlation;
- estimate a final concentration of a dilution analyte in the plasma based at least in part on the correlation;
- determine a dilution factor of the plasma by comparing the final concentration of the dilution analyte with a known initial concentration of dilution analyte;
- determine a relative volume of the plasma;
- and
- estimate a presence of a test analyte in the plasma based at least in part on the correlation, the dilution factor and the relative volume.
8 more elements
A method for determining the amount of an analyte of interest in an unknown quantity of sample comprising:
- providing three reaction channels each containing a reagent that reacts with the analyte to produce either a first detectable signal proportional to the amount of the analyte in the reaction channel or a reaction product that can be further reacted to produce the first detectable signal proportional to the amount of the analyte in the reaction channel,
- the first reaction channel containing a known first quantity of the analyte of interest n,
- the second reaction channel containing a known second quantity of the analyte of interest m, wherein m is different than m,
- and the third reaction channel containing a known third quantity of the analyte of interest o, wherein o≠m or n,
- depositing a volume of the sample in each of the reaction channels;
- measuring the first detectable signal produced in each reaction channel;
- and
- determining the amount of analyte in the unknown sample based on the method of standard addition.
5 more elements
Dependencies are inferred from the claim text.