PERSONALIZED ctDNA DISEASE MONITORING VIA REPRESENTATIVE DNA SEQUENCING
AssigneesVentana Medical Systems, Inc., The Francis Crick Institute Limited, The Royal Marsden NHS Foundation Trust
InventorsNelson R. Alexander, Kevin Richard Litchfield, Stacey Stanislaw, Samra Turajlic
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Abstract
Disclosed herein is a method of deriving a plurality of genetic variants from a homogenized input sample. Also disclosed herein are methods of identifying a plurality of genetic variants in a sample comprising: homogenizing one or more input samples to provide a homogenized sample; preparing genomic material isolated from the homogenized input sample for sequencing; and identifying the plurality of genetic variants within sequencing data derived after sequencing the prepared genomic material.
Claims21
A method of identifying a plurality of genetic variants in a sample comprising:
- (a) homogenizing one or more tumor samples to provide a homogenized sample;
- (b) preparing genomic material isolated from the homogenized sample for sequencing;
- and
- (c) identifying the plurality of genetic variants within sequencing data derived after sequencing the prepared genomic material.
Dependencies are inferred from the claim text.