Loading patent…
AssigneesPeking University, Institute of Biophysics, Chinese Academy of Sciences, Institute of Laboratory Animal Science, Chinese Academy of Medical Science
InventorsFuping YOU, Xiangxi WANG, Chuan QIN
Estimating the term…
The present disclosure relates to a method for preventing and treating or diagnosing coronavirus infection. SARS-CoV2 lung infection animal models are established using rhesus macaques and human ACE2 transgenic mice, innate immune characteristics that occur in the body in the early stage of SARS-CoV2 infection are explored, and S100A8 protein is found as the root cause initiating the inflammatory storm and becomes an immune indicator for early diagnosis of a patient with SARS-CoV2 infection. Then inhibition of the function of S100A8/S100A9 dimer finally inhibits the virus titer in tissues, thereby decreasing the inflammation level, which proves that a dimer inhibitor can be used as an effective drug for preventing and treating coronavirus infection.
A method for preventing and treating a disease caused by a coronavirus in a subject in need thereof comprising administering to the subject an effective amount of an S100A8/S100A9 dimer activity inhibitor.
A method for diagnosing coronavirus infection, comprising detecting the amount of S100A8 protein or its gene expression level, the amount of S100A9 protein or its gene expression level, or the amount of S100A8/S100A9 dimer.
A method for screening a compound useful for preventing and treating or alleviating coronavirus infection, comprising measuring the expression level of S100A8 gene and/or S100A9 gene, or the amount of S100A8 and/or S100A9 in a sample.
A method for pathological state and drug evaluation for the novel coronavirus pneumonia, comprising using an IFNAR gene knockout animal model with manifestations of severe pneumonia, or comprising detecting abnormal proliferation of immature neutrophils in the animal model.
An animal model, which is an IFNAR gene knockout animal model with manifestations of severe pneumonia.
Dependencies are inferred from the claim text.