Loading patent…
AssigneePurdue Research Foundation
InventorsShelley A. Claridge, Tyson C. Davis, Sarah Calve, Alita Miller, Anamika Singh
Estimating the term…
This present disclosure relates to a designed material surface mimicking properties of an extracellular matrix or matrisome, as a means for modulating cell adhesion, spreading, proliferation, differentiation, or reprogramming; and for controllable, directional cell adhesion, spreading, proliferation, differentiation, or reprogramming. In particular, this present disclosure relates to a designed material surface mimicking properties of large polysaccharides for modulating cell adhesion, proliferation, differentiation, or reprogramming of a cell, and to materials for scaffolding cell growth. Processes and composition matters are within the scope of this patent application.
A surface-functionalized cell culture support, wherein the surface of the support material is modified by a transferred monolayer of polymerized striped phases of molecules comprising one or more chemical functional groups, one or more long alkyl chains, and one or more polymerizable functional groups;
A transferred striped monolayer compatible to be added to a traditional cell culture support comprising polymerized striped phases of molecules comprising one or more chemical functional groups, one or more long alkyl chains, and one or more polymerizable functional groups, wherein said transferred striped monolayer is useful for modulating directional adhesion, proliferation, differentiation, or reprogramming of a cell.
A surface or a template comprising a monolayer of a polymerized striped phase with chemical functional groups, wherein the structure of said striped phase spatially controls arrangement of said functional groups with elements of the spatial placement occurring at sub-10-nm scales, and wherein said striped monolayer mimics properties of macromolecules or components of the extracellular matrix useful for modulating the directional adhesion, proliferation, differentiation, or reprogramming of a cell.
Dependencies are inferred from the claim text.