Gradient Injection Comprising a Mixture of Polymer Microspheres

Abstract

Provided is a gradient injection containing a mixture of polymer microspheres. The injection is a freeze-dried powder composed of a filler, cross-linked sodium hyaluronate microspheres, poly-L-lactic acid (PLLA) microspheres, and an excipient. The powder can be mixed with sterile water and then used for injection cosmetology. A triple gradient effectiveness is provided by mixing the filler, the cross-linked sodium hyaluronate microspheres, and the PLLA microspheres to improve the subcutaneous capacity of human skin and repair skin wrinkles, folds, scars, and aging. The gradient injection is also suitable for repairing large-volume facial fat loss without adverse reactions such as nodules and granulomas.

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