Star Polypeptides
AssigneeThe Royal College of Surgeons Ireland
InventorsSally-Ann Cryan, Andreas Heise, David Walsh, Joanne O'Dwyer, Fergal O'Brien, Garry Duffy
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Abstract
A star polypeptide for use as a medicament, the star polypeptide comprising or consisting of a core and polypeptide arms radiating from the core. The star polypeptide may be used to deliver a therapeutic cargo and/or for its intrinsic properties. Therapeutic cargoes include a protein(e.g. VEGF); a nucleic acid (e.g. in vitro transcribed mRNA or microRNA); and/or a drug (e.g. diclofenac, azithromycin and/or rifampicin). Intrinsic properties include osteogenesis, angiogenesis and inhibition of bacteria.
Claims23
A method of stimulating a response in a subject or in a cell culture comprising the step of:
- administering a composition to the subject or to the cell culture, the composition comprising a star polypeptide and optionally a therapeutic cargo, the star polypeptide comprising or consisting of a core and polypeptide arms radiating from the core, thereby stimulating a response in the subject or in the cell culture.
(canceled)
(canceled)
A composition comprising a star polypeptide and (i) a protein, (ii) a nucleic acid and/or (iii) a drug, the star polypeptide comprising a core and polypeptide arms radiating from the core.
A composition comprising a star polypeptide and (i) a scaffold and/or (ii) a hydrogel;
- the star polypeptide comprising a core and polypeptide arms radiating from the core.
(canceled)
Dependencies are inferred from the claim text.