Antigen binding formats for receptor complexes
OwnerYang LI, Parthasarathy SAMPATHKUMARinventors
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Abstract
The present invention provides multispecific multivalent antigen binding molecules that can function as surrogate molecules by binding and activating at least two receptors. The present invention provides a molecule comprising a plurality of antigen binding domains, wherein the binding domains bind to at least one first receptor and at least one second receptor, and related uses thereof.
Claims29
A molecule comprising at least two Fab binding domains and an Ig domain, wherein at least one Fab binding domain binds to at least one receptor of a Wnt co-receptor complex.
A polypeptide comprising or consisting of a polypeptide sequence having at least 70%, at least 80%, at least 90%, at least 95%, at least 98%, or at least 99% sequence identity to a sequence selected from SEQ ID NOs:
- 1-40.
Dependencies are inferred from the claim text.