Anti-idiotype antibodies targeting anti-bcma chimeric antigen receptor
OwnerHenia DAR, Lalit KUMARinventors
Life of this patent
Estimating the term…
Abstract
High affinity antibodies capable of binding to a single-chain variable fragment (scFv) of anti-BCMA antibody, for example, the scFv expressed on cell surface as a portion of a chimeric antigen receptor (CAR). Also provided herein are methods for producing such anti-scFv antibodies and methods of using the antibodies disclosed herein for detecting, for example, T cells expressing an anti-BCMA CAR that comprise the scFv as an extracellular domain.
Claims25
An isolated antibody, which binds a single-chain variable fragment (scFv) consisting of the amino acid sequence of SEQ ID NO:1, wherein the antibody binds the same epitope of the scFv as reference antibody 15C04-02F03, or competes against the reference antibody for binding to the scFv.
Dependencies are inferred from the claim text.