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AssigneeThe University of North Carolina at Chapel Hill
InventorsRihe LIU, Gianpietro DOTTI, JingJing LI, Jiyoung AHN
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Provided herein are biepitopic or bispecific chimeric antigen receptors. The chimeric antigen receptors comprise a combination of single domain antibody mimics The single domain antibody mimics may be monobodies, affibodies, or DARPins. The disclosed chimeric antigen receptors may recognize two different epitopes of the same tumor antigen. For example, the chimeric antigen receptor may recognize two different epitopes of HER-2 or EGFR. The disclosed chimeric antigen receptors may recognize two epitopes of two different tumor antigens. For example, the chimeric antigen receptor may recognize HER-2 and EGFR. The disclosed chimeric antigen receptors may be expressed in immune cells for use in cancer immunotherapy.
A chimeric antigen receptor (CAR) comprising:
The chimeric antigen receptor of any one of claims 12-16, wherein the chimeric antigen receptor comprises a polypeptide sequence having at least 90% sequence identity to SEQ ID NO:
Dependencies are inferred from the claim text.