Binding molecule specific for cd73 and use of binding molecule
AssigneeJacobio Pharmaceuticals Co., Ltd.
InventorsQinghao LIU, Wenlai ZHOU, Haiyan YANG, Hongling WANG
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Abstract
A binding molecule specific for CD73 and a use of the binding molecule. Specifically, provided are a separate antibody binding CD73 and inhibiting the activity of CD73 or an antigen binding part of the separate antibody, and a use of the separate antibody or the antigen binding part thereof in treatment of diseases; also provided are a nucleic acid molecule encoding the separate antibody or the antigen binding part thereof, an expression vector for expressing the separate antibody or the antigen binding part thereof, a host cell, and a preparation method.
Claims19
1-71. (canceled)
An isolated antibody or antigen-binding fragment thereof comprising a heavy chain variable region that comprises HCDR1, HCDR2, HCDR3;
- and a light chain variable region that comprises LCDR1, LCDR2, LCDR3, wherein:
- (a) HCDR1 comprises the amino acid sequence of SEQ ID NO:
- 18;
- (b) HCDR2 comprises the amino acid sequence of SEQ ID NO:19;
- (c) HCDR3 comprises the amino acid sequence of SEQ ID NO:20;
- (d) LCDR1 comprises the amino acid sequence of SEQ ID NO:23;
- (e) LCDR2 comprises the amino acid sequence of SEQ ID NO:24;
- and
- (f) LCDR3 comprises the amino acid sequence of SEQ ID NO:
- 25.
Dependencies are inferred from the claim text.