LTBP COMPLEX-SPECIFIC INHIBITORS OF TGFb AND USES THEREOF

An antibody, or an antigen-binding fragment thereof, that specifically binds a human latent transforming growth factor beta binding protein 1 (LTBP1)-proTGFβ complex and a human latent transforming growth factor beta binding protein 3 (LTBP3)-proTGFβ complex, comprising a heavy chain variable domain and a light chain variable domain,

• wherein the heavy chain variable domain comprises:
• a heavy chain complementary determining region 1 (CDRH1) comprising an amino acid sequence set forth as SEQ ID NO:
• 166,
• a heavy chain complementary determining region 2 (CDRH2) comprising an amino acid sequence set forth as SEQ ID NO:
• 167, and
• a heavy chain complementary determining region 3 (CDRH3) comprising an amino acid sequence set forth as SEQ ID NO:
• 168;
• and
• wherein the light chain variable domain comprises:
• a light chain complementary determining region 1 (CDRL1) comprising an amino acid sequence set forth as SEQ ID NO:
• 169,
• a light chain complementary determining region 2 (CDRL2) comprising an amino acid sequence set forth as SEQ ID NO:
• 170, and,
• a light chain complementary determining region 3 (CDRL3) comprising an amino acid sequence set forth as SEQ ID NO:
• 171.