Methods for treating tauopathies
AssigneeWashington University
InventorsRandall Bateman, David Holtzman, Kanta Horie, Nicolas Barthelemy, Chihiro Sato, Hong Jiang
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Abstract
This invention relates to epitope binding agents that specifically bind to tau and methods of use thereof. The disclosure provides immunoassays, kits, and pharmaceutical compositions which include an epitope binding agent that specifically bind to tau. The disclosure provides methods of reducing the spread of tau aggregates and methods of reducing a tauopathy-related pathology.
Claims10
An isolated antibody or antigen-binding fragment, wherein the isolated antibody or antigen-binding fragment specifically binds tau and
- (a) recognizes an epitope within SEQ ID NO:
- 3 (LQTAPVPMPDLK), SEQ ID NO:
- 6 (HVPGGGSVQIVYKPVDLSK), and SEQ ID NO:
- 7 (IGSLDNITHVPGGGNK);
- or
- (b) recognizes an epitope comprising four or more continuous amino acids of an amino acid sequence selected from the group consisting of SEQ ID NO:
- 3 (LQTAPVPMPDLK), SEQ ID NO:
- 6 (HVPGGGSVQIVYKPVDLSK), and SEQ ID NO:
- 7 (IGSLDNITHVPGGGNK);
- or
- (c) recognizes an epitope comprising an amino acid sequence selected from the group consisting of SEQ ID NO:
- 3 (LQTAPVPMPDLK), SEQ ID NO:
- 6 (HVPGGGSVQIVYKPVDLSK), and SEQ ID NO:
- 7 (IGSLDNITHVPGGGNK).
An immunoassay comprising an isolated antibody or antigen-binding fragment, wherein the isolated antibody or antigen-binding fragment specifically binds tau and
- (a) recognizes an epitope within SEQ ID NO:
- 3 (LQTAPVPMPDLK), SEQ ID NO:
- 6 (HVPGGGSVQIVYKPVDLSK), and SEQ ID NO:
- 7 (IGSLDNITHVPGGGNK);
- or
- (b) recognizes an epitope comprising four or more continuous amino acids of an amino acid sequence selected from the group consisting of SEQ ID NO:
- 3 (LQTAPVPMPDLK), SEQ ID NO:
- 6 (HVPGGGSVQIVYKPVDLSK), and SEQ ID NO:
- 7 (IGSLDNITHVPGGGNK);
- or
- (c) recognizes an epitope comprising an amino acid sequence selected from the group consisting of SEQ ID NO:
- 3 (LQTAPVPMPDLK), SEQ ID NO:
- 6 (HVPGGGSVQIVYKPVDLSK), and SEQ ID NO:
- 7 (IGSLDNITHVPGGGNK).
A kit comprising an isolated antibody or antigen-binding fragment, wherein the isolated antibody or antigen-binding fragment specifically binds tau and
- (a) recognizes an epitope within SEQ ID NO:
- 3 (LQTAPVPMPDLK), SEQ ID NO:
- 6 (HVPGGGSVQIVYKPVDLSK), and SEQ ID NO:
- 7 (IGSLDNITHVPGGGNK);
- or
- (b) recognizes an epitope comprising four or more continuous amino acids of an amino acid sequence selected from the group consisting of SEQ ID NO:
- 3 (LQTAPVPMPDLK), SEQ ID NO:
- 6 (HVPGGGSVQIVYKPVDLSK), and SEQ ID NO:
- 7 (IGSLDNITHVPGGGNK);
- or
- (c) recognizes an epitope comprising an amino acid sequence selected from the group consisting of SEQ ID NO:
- 3 (LQTAPVPMPDLK), SEQ ID NO:
- 6 (HVPGGGSVQIVYKPVDLSK), and SEQ ID NO:
- 7 (IGSLDNITHVPGGGNK).
Dependencies are inferred from the claim text.