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US 2022/0064244 A1Published application
A polypeptide molecule and application thereof
AssigneeSunshine Lake Pharma Co., Ltd.
InventorsChao CHEN, Shushan LIN, Yu LI, Xiaoping LI, Xiaofeng CHEN, Wenjia LI, Liang LIU, Zheng FU
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Abstract
An FGF21 polypeptide has one or more of the following properties: stable structure, long half-life, low immunogenicity, high biological activity, and enhanced glucose-lowering and lipid-lowering activities. A fusion protein or immunoconjugate includes the FGF21 polypeptide.
Claims21
-42. (canceled)
An FGF21 polypeptide, which comprises amino acid substitutions at the following positions:
- L98, S167, P171, R175 and R19, as compared to the amino acid sequence shown in SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.