Antibodies against disease causing agents of canines and felines and uses thereof
AssigneeNovobind Livestock Therapeutics Inc.
InventorsHamlet ABNOUSI, Slade Andrew LOUTET, Filip VAN PETEGEM, Tsz Ying Sylvia CHEUNG
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Abstract
Described herein are methods and antibodies useful for reducing, eliminating, or preventing infection with a viral population in an animal. Also described herein are antigens useful for targeting by heavy chain antibodies and VHH fragments for reducing a viral population in an animal.
Claims24
A polypeptide comprising at least one variable region fragment of a heavy chain antibody (VHH), wherein the at least one VHH specifically binds a parvovirus, wherein the polypeptide:
- a) prevents red blood cell hemagglutination by canine parvovirus type 2C capsid at a concentration lower than 100 nM;
- b) prevents red blood cell hemagglutination by canine parvovirus type 2C capsid at a concentration lower than 1 μM;
- or c) reduces invasion of MDCK cells by canine parvovirus by >50% at 5 μM.
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Dependencies are inferred from the claim text.