Hydrophobic interaction chromatography carrier and protein purification method
AssigneeJnc Corporation
InventorsKojiro SOTA, Yoshihiro MATSUMOTO
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Abstract
A chromatography carrier capable of removing an antibody dimer from a solution containing an antibody monomer. The chromatography carrier includes a base carrier containing porous particles and a hydrophobic ligand bound to the base carrier, and has an electric conductivity of 34 mS/cm or less measured by a gradient elution test. The porous particles preferably have an average particle diameter of 66 to 150 μm, and the hydrophobic ligand preferably has at least one selected from a group consisting of phenyl, n-butyl, n-hexyl, n-octyl, and n-octadecyl.
Claims8
A chromatography carrier, comprising a base carrier containing porous particles and a hydrophobic ligand bound to the base carrier, and
- having an electric conductivity of 34 mS/cm or less measured by a gradient elution test.
Dependencies are inferred from the claim text.