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US 2022/0064208 A1Published application
Process for solid-phase peptide synthesis and device
OwnerOliver Johannes KREUZERinventor
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Abstract
The invention relates to a method for carrying out solid-phase peptide synthesis, to an automated parallel solid-phase peptide synthesis, and to a device designed to carry out such a method. According to the invention, ultrasound with a frequency of more than 25 kHz acts at least intermittently during the method on the reaction medium in which the solid-phase peptide synthesis takes place.
Claims19
A method for carrying out solid-phase peptide synthesis comprising the steps of
- a) binding an amino acid protected at the N-terminus by a protecting group to a solid support material via a C-terminus of the amino acid,
- b) splitting off the protecting group,
- c) performing at least one peptide propagation and
- d) terminating the reaction by splitting off the peptide from the support material,
- wherein steps a) to d) take place in a liquid reaction medium and, at least during one of the steps, ultrasound with a frequency in the range of 25 to 2000 kHz acts at least intermittently on the reaction medium.
2 more elements
Dependencies are inferred from the claim text.