Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof

A compound of formula (R)-G-8:

• wherein
• [acyl] is RxC(O)—, wherein Rx is optionally substituted C1-4 aliphatic;
• Ra is an optionally substituted group selected from a 3-7 membered ring having 0-2 heteroatoms selected from nitrogen, oxygen, and sulfur, and a C1-6 aliphatic;
• R2 is hydrogen, or optionally substituted C1-6 aliphatic;
• and
• R5 is hydrogen or halogen.

A compound of formula (R)-G-1:

• wherein
• RH is a leaving group;
• Ra is an optionally substituted group selected from a 3-7 membered ring having 0-2 heteroatoms selected from nitrogen, oxygen, and sulfur, and a C1-6 aliphatic;
• R2 is hydrogen, or optionally substituted C1-6 aliphatic;
• and
• R5 is hydrogen or halogen.

A process for preparing Compound 1:

• or a salt or co-crystal thereof, comprising:
• (a) contacting compound G-2-a:
• with oxazole under conditions sufficient to form compound G-9-a:
• (b) contacting compound G-9-a with compound (R)-G-1-a:
• under conditions sufficient to form a compound G-4-a:
• (c) hydrolyzing compound G-4-a under conditions sufficient to form Compound 1.