Imidazo-pyrazole carboxamide derivatives as anticancer agents and the synthesis thereof

Novel bicyclic imidazo[1,2-b]pyrazole carboxamide and carbothioamide derivatives and pharmaceutically acceptable salts thereof

• wherein in general formula (V)
• R1 represents hydrogen;
• branched or unbranched C1-C8-alkyl, aralkyl or aryl group;
• furthermore represents heteroaryl group and heterocycles in saturated or unsaturated forms containing O, N and/or S atoms;
• R2 represents hydrogen and branched or un-branched C1-C8-alkyl group;
• R3 represents aliphatic branched or unbranched C1-C8-alkyl, aralkyl or aryl group;
• furthermore represents heteroaryl group and heterocycles in saturated or unsaturated forms containing O, N and/or S atoms;
• R4 represents aliphatic branched or unbranched C1-C8-alkyl group;
• CH2R′ group wherein R′ represents hydrogen, branched or unbranched C1-C8 alkyl group;
• CO(OR″) group, wherein R″ represents branched or unbranched C1-C8 alkyl;
• aralkyl or aryl group;
• furthermore represents heteroaryl group and heterocycles in saturated or unsaturated forms containing O, N and/or S atoms;
• C(O)R′ group, wherein R′ represents heteroaryl group;
• and
• X represents O- or S-atom.