Harmine synthesis
AssigneeAnkh Life Sciences Limited
InventorsGene H. Zaid, Krishna Mohan Donavalli, Rajni Verma
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Abstract
Methods for the synthesis of harmine comprise reacting harmaline with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) in the presence of a diacid catalyst. In an embodiment, the synthesis is carried out using a reaction mixture of harmaline, DDQ, THF solvent, and succinic acid; the reaction is carried out under an inert atmosphere with refluxing for a period of 4-12 hours.
Claims11
A method of synthesizing harmine comprising the steps of reacting a reaction mixture comprising harmaline with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) in a compatible solvent and in the presence of an acid catalyst, and thereafter recovering harmine.
Dependencies are inferred from the claim text.