Novel heterocyclic amine derivative and pharmaceutical composition comprising same
AssigneeDaewoong Pharmaceutical Co., Ltd.
InventorsWol Young Kim, Yeon Im Lee, Youn Jung Yoon, Joon Seok Park, Deok Ki Eom, Keuk-Chan Bang, Jaehyun Jung
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Abstract
The present disclosure relates to a novel heterocyclic amine derivative represented by the following Chemical Formula 1 and a pharmaceutical composition comprising the same, and the compound according to the present disclosure can be usefully used for the prevention or treatment of autoimmune diseases or cancers. wherein, in Chemical Formula 1, R1, R2, X1, X2, L, Y, A and B are the same as defined in the specification.
Claims15
A compound represented by the following Chemical Formula 1, or a pharmaceutically acceptable salt thereof:
- wherein, in Chemical Formula 1,
- B is a 5-membered or 6-membered heterocycle containing 1 to 3 heteroatoms each independently selected from the group consisting of N, O and S, provided that the 5-membered or 6-membered heterocycle includes at least one N,
- R1 is hydrogen, halogen, C1-4 alkyl, or C1-4 haloalkyl,
- X1 and X2 are each independently N, or CR′,
- wherein R′ is hydrogen or halogen,
- L is a bond, C1-4 alkylene, or —O—,
- R2 is cyano;
- C1-4 alkyl;
- C6-10 aryl;
- pyridinyl;
- morpholino;
- piperazinyl;
- or piperidinyl,
- wherein, the piperazinyl and the piperidinyl are each independently, unsubstituted, or substituted with C1-4 alkyl, C1-4 alkyl substituted with cyano, C1-4 alkyl substituted with amino, C1-4 alkyl substituted with C1-4 alkoxy, or —CO—(C1-4 alkyl),
- Y is a bond, —O—, —NH—, or —N(C1-4 alkyl)-,
- A is C1-4 alkyl,
- wherein R3 is C1-4 alkyl, C1-4 haloalkyl, C2-4 alkenyl, C2-4 haloalkenyl, C2-4 alkynyl, or C2-4 haloalkynyl.
Dependencies are inferred from the claim text.