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US 2022/0064152 A1Published application
Novel fungal modulators
AssigneeTrustees of Boston University
InventorsLauren E. BROWN, Kaddy CAMARA, Leah E. COWEN, John A. PORCO, JR.
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Abstract
The present invention is directed to compounds, compositions, and methods for inhibiting drug-efflux pumps. The compounds, compositions, and methods can be used for enhancing the activity of therapeutic agents that are efflux pump substrates and for the treatment of drug-resistant diseases or disorders, such as microbial infections and cancers.
Claims20
A compound of Formula (I):
- or enantiomers, prodrugs, derivatives, and pharmaceutically acceptable salts thereof,
- wherein:
- each of R40, R50, R60, R70, and R80 independently are hydrogen, halogen, hydroxyl, amino, alkylamino, dialkylamino, acylamino, thiol, alkylthio, cyano, carbonyl, carboxyl, alkoxycarbonyl, nitro, acyl, acyloxy, alkyl, haloalkyl, heteroalkyl, alkoxy, alkenyl, alkynyl, sulfinyl, sulfonyl, thiocarbonyl, carbamoyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, and each of which can be optionally substituted;
- Ar1 and Ar2 are each independently optionally substituted aryl or optionally substituted heteroaryl;
- and
- provided that the compound is not oxyphenisatin, isatin bis-cresol or MS-8396.
3 more elements
The compound of claim 5, wherein R80 is hydrogen, optionally substituted C1-C6alkyl, optionally substituted C2-C8alkenyl, or optionally substituted C2-C8alkynyl, optionally R80 is H.
Dependencies are inferred from the claim text.