Kinase inhibitor compounds and compositions and methods of use

A compound of formula (I) having the following structure:

• or a stereoisomer, pharmaceutically acceptable salt, oxide, or solvate thereof, wherein
• R1 and R6 are independently optionally present, and when present, each is independently selected from H, substituted or unsubstituted C1-C6 alkyl, halogen, —CF3, —OCF3, or a substituted or unsubstituted cycloalkyl;
• R2 is selected from H, substituted or unsubstituted C1-C6 alkyl, halogen, —CF3, —OCF3, substituted or unsubstituted cycloalkyl, or substituted or unsubstituted aryl or heteroaryl;
• R3 is optionally present, and when present is an oxygen that forms a carbonyl, or a substituted or unsubstituted C1-C6 alkyl;
• R4 is NH, carbonyl, or branched or unbranched C1-C6 alkyl;
• R5 is optionally present, and when present is a substituted or unsubstituted C1-C6 alkyl, halogen, —CF3, or —OCF3;
• is a single or double bond;
• X is C, CH, O, or N;
• N—Ar is selected from pyridazine, pyrazine, and pyrimidine;
• Y is a bond, NH, or branched or linear C1-C6 substituted or unsubstituted alkyl;
• and
• Z is H or a substituted or unsubstituted aryl, biaryl, heteroaryl, cycloalkyl, heterocycle, or alkyl, wherein said substituent is selected from hydroxyl, —CF3, —OCF3, halogen, nitrile, aryl, C1-C6 alkoxy, amide, amino, alkyl, aminocarboxamide, substituted or unsubstituted carboxamide, or a C1-C6 alkyl ester.