Compounds for and methods of treating diseases

A compound of formula (Ib):

• wherein X is O;
• R1 is selected from:
• R6 and R7 are independently selected from hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, hydroxy, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy, halo, CN, CO2R9 and N(R9)2;
• or
• R6 and R7 taken together with the atoms to which they are attached form an unsubstituted 6 membered aryl or heteroaryl ring;
• each R8 is independently selected from hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, hydroxy, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy, halo, (CH2)mCO2R9 and (CH2)mN(R9)2;
• each R9 is independently selected from hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl and C1-6haloalkyl;
• R2 is selected from hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-8 cycloalkyl and
• R1 and R2 taken together form
• wherein V is CH, O or S and R11 and R12 are each independently selected from hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, halo, C1-6haloalkyl, (CH2)mC3-8cycloalkyl, (CH2)maryl, (CH2)mheterocyclyl, (CH2)mheteroaryl and COR13 where R13 is selected from OH, OC1-6alkyl, OC2-6alkenyl, OC2-6alkynyl and N(R9)2, wherein the cycloalkyl, heterocycloalkyl or heteroaryl ring of the bicyclic structure formed by R1 and R2 may be optionally substituted, or
• R1 and R2 are both:
• R3 is selected from hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl and C(R10)2)mCO2R9;
• R4 and R4a are each independently selected from hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl and C1-6haloalkyl;
• and R5 is hydrogen, (C(R10)2)maryl, (C(R10)2)mheteroaryl, O(C(R10)2)maryl or O(C(R10)2)mheteroaryl wherein the aryl and heteroaryl are optionally substituted;
• or
• R4a is CN and R4 and R5 are both hydrogen or taken together form:
• where R14 is hydrogen, (C(R10)2)maryl or (C(R10)2)mheteroaryl wherein the aryl and heteroaryl are optionally substituted;
• or
• R4a is absent and R4 and R5 taken together form an optionally substituted aryl or optionally substituted heteroaryl group;
• each R10 is independently selected from hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, hydroxy, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy, CN, halo and N(R9)2;
• m is 0 or an integer of 1 to 6;
• or a pharmaceutically acceptable salt thereof.