Benzopyridone heterocyclic compound and use thereof

A compound represented by formula I, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, or a tautomer thereof, or a hydrate thereof, or a solvate thereof, or a metabolite thereof, or a prodrug thereof,

• wherein,
• R1 is independently selected from an aryl optionally substituted with a plurality of R6, or a heteroaryl optionally substituted with a plurality of R6;
• and when R1 is substituted with a plurality of R6, each R6 may be the same as or different from each other;
• R2 is independently selected from an aryl optionally substituted with a plurality of R7, or a heteroaryl optionally substituted with a plurality of R7;
• and when R2 is substituted with a plurality of R7, each R7 may be the same as or different from each other;
• R3 is selected from H, halogen, cyano, amide group, hydroxy, amino, C1-C3 alkyl, C1-C3 heteroalkyl, C1-C3 haloalkyl, or C3-C8 heterocycloalkyl;
• said C1-C3 alkyl, C1-C3 heteroalkyl, C1-C3 haloalkyl, or C3-C8 heterocycloalkyl is optionally substituted with 0 to 3 R7, and when said C1-C3 alkyl, C1-C3 heteroalkyl, C1-C3 haloalkyl, or C3-C8 heterocycloalkyl is substituted with a plurality of R7, each R7 may be the same as or different from each other;
• R4 and R5 are each independently selected from H, halogen, C1-C8 alkyl optionally substituted with 0 to 3 R7, or C1-C8 heteroalkyl optionally substituted with 0 to 3 R7;
• is selected from C4-C8 monoheterocycloalkyl optionally substituted with 0 to 3 R8, C6-C12 bridged heterocycloalkyl optionally substituted with 0 to 3 R8, or C6-C12 spiroheterocycloalkyl optionally substituted with 0 to 3 R8;
• R6 is selected from halogen, OH, CN, NH2, C1-C8 alkyl, C1-C8 heteroalkyl, C1-C3 haloalkyl, C1-C3 haloalkoxy, C3-C8 cycloalkyl, or C3-C8 heterocycloalkyl;
• wherein said C1-C8 alkyl, C1-C8 heteroalkyl, C1-C3 haloalkyl, C1-C3 haloalkoxy, C3-C8 cycloalkyl, or C3-C8 heterocycloalkyl may be substituted with a plurality of the following groups:
• F, Cl, Br, I, OH, CN, NH2, CH3, CH3CH2, CH3O, CF3, CHF2, CH2F, cyclopropyl, isopropyl, N(CH3)2, and NH(CH3)2;
• R7 is selected from halogen, OH, CONH2, CN, NH2, C1-C8 alkyl, C1-C8 heteroalkyl, C1-C3 haloalkyl, C1-C3 haloalkoxy, C3-C8 cycloalkyl, or C3-C8 heterocycloalkyl, wherein said C1-C8 alkyl, C1-C8 heteroalkyl, C1-C3 haloalkyl, C1-C3 haloalkoxy, C3-C8 cycloalkyl, or C3-C8 heterocycloalkyl may be substituted with a plurality of the following groups:
• F, Cl, Br, I, OH, CN, NH2, CH3, CH3CH2, CH3O, CF3, CHF2, CH2F, cyclopropyl, isopropyl, N(CH3)2, and NH(CH3)2;
• and
• R8 is selected from H, halogen, CN, OH, C1-C3 alkyl, halogen-substituted C1-C3 alkyl, or cyano-substituted C1-C3 alkyl.