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US 2022/0064135 A1Published application
Method for Preparation of 1,4-Sorbitan in Aqueous Medium
AssigneesLonza Guangzhou Pharmaceutical Ltd., Lonza Ltd.
InventorsJieping Wei, Gesa Paradies, Benjamin Wyler, Dieter Scherer, Yanling Yang, Xiaolong Zhang, Weicheng Jiang, Reta Zhu
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Abstract
The invention discloses a method for preparation of 1,4-sorbitan by dehydration of D-sorbitol in aqueous medium, wherein one equivalent of water is removed and a cyclization occurs, followed by a treatment with ethanol and isopropanol.
Claims17
A method for preparation of 1,4-sorbitan with three consecutive steps STEP1, STEP2 and STEP3, wherein
- in STEP1 D-sorbitol is dehydrated in a dehydration reaction DEHYDREAC in the presence of p-toluenesulfonic acid and tetrabutylammonium bromide, STEP1 provides a mixture MIX1;
- in STEP2 ethanol is mixed with MIX1, STEP2 provides a mixture MIX2;
- in STEP3 isopropanol is mixed with MIX2, STEP3 provides a mixture MIX3;
- D-sorbitol is used for STEP1 in form of a mixture of D-sorbitol with water.
1 more element
Dependencies are inferred from the claim text.