Platelet aggregation inhibitor, preparation and uses thereof
AssigneeShenyang Hinewy Pharmaceutical Technology Co., Ltd.
InventorsShaojie WANG, Yu LEI, Bing ZHANG
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Abstract
This disclosure relates to medicines, and more particularly to a platelet aggregation inhibitor, a pharmaceutical composition containing the same and a preparation and application thereof. The platelet aggregation inhibitor provided herein is a compound of formula (I), or a pharmaceutically-acceptable salt, a tautomer or a pharmaceutically-acceptable solvate thereof. This application also provides an application of the compound of formula (I), or a pharmaceutically-acceptable salt, a tautomer, a pharmaceutically-acceptable solvate or a pharmaceutical composition thereof in the treatment of thrombus.
Claims10
A compound of formula (I), or a pharmaceutically-acceptable salt, a tautomer or a pharmaceutically-acceptable solvate thereof:
- wherein R1 is selected from the group consisting of hydrogen, hydroxyl, cyano, tetrazolyl, triazolyl, imidazolyl, nitro, halogen, C1-C8 linear and branched alkyl, C3-C8 cycloalkyl, C1-C8 linear and branched alkyloxy, C3-C8 cycloalkyloxy, C1-C8 linear and branched aliphatic alkylamino, C3-C8 aliphatic cycloalkylamino, C2-C8 linear and branched alkenyl, C2-C8 linear and branched alkenyloxy, C2-C8 linear and branched alkenylamino, C2-C8 linear and branched alkynyl, C2-C8 linear and branched alkynyloxy, C2-C8 linear and branched alkynylamino, and substituted and unsubstituted C6-C10 aryl, wherein a substituent on the substituted C6-C10 aryl is selected from the group consisting of halogen, hydroxyl, cyano, nitro, C1-C6 alkyl, C1-C6 alkyloxy, C1-C6 alkylamino, C1-C6 alkylcarbonyl, C1-C6 alkyloxycarbonyl and C1-C6 alkylaminocarbonyl;
- R2 is selected from the group consisting of hydrogen, hydroxyl, C1-C8 linear and branched alkyl, C3-C8 cycloalkyl, C2-C8 linear and branched alkenyl, C2-C8 linear and branched alkynyl, —(CH2)n—COOH, —(CH2)n—OH, —(CH2)n—CONH2, —(CH2)n—NHOC(CH2)mCH3, —(CH2)n—COOC(CH2)mCH3, and substituted and unsubstituted C6-C10 aryl, wherein a substituent on the substituted C6-C10 aryl is selected from the group consisting of halogen, hydroxyl, cyano, nitro, C1-C6 alkyl, C1-C6 alkyloxy, C1-C6 alkylamino, —(CH2)n—COOH, —(CH2)n—OH, —(CH2)n—CONH2, —(CH2)n—NHOC(CH2)mCH3 and —(CH2)n—COOC(CH2)mCH3;
- and n is selected from 1-6, and m is selected from 1-3;
- A is selected from the group consisting of nitrogen atom, oxygen atom, hydrogen atom, carbon atom, and sulfur atom;
- R3 is selected from the group consisting of hydrogen, cyano, tetrazolyl, triazolyl, imidazolyl, 1,2,4-oxadiazolyl, nitro, halogen, C1-C6 alkyl, C1-C6 alkylamino, and C1-C6 alkoxy;
- R4 is selected from the group consisting of C1-C6 alkyl and substituted and unsubstituted C6-C10 aryl, wherein a substituent on the substituted aryl is selected from the group consisting of halogen, C1-C6 alkylamino, C1-C6 alkyl, C1-C6 alkoxy, nitro, hydroxyl, cyano, and amino;
- R5 is selected from the group consisting of hydrogen, cyano, tetrazolyl, triazolyl, imidazolyl, 1,2,4-oxadiazolyl, nitro, fluorine, chlorine, bromine, C1-C6 alkyl, C1-C6 alkylamino, and C1-C6 alkoxy;
- R6 is selected from the group consisting of hydrogen, C1-C6 alkyl, C1-C6 alkylamino, C1-C6 alkoxy and substituted and unsubstituted C6-C10 aryl, wherein a substituent on the substituted aryl is selected from the group consisting of halogen, C1-C6 alkylamino, C1-C6 alkoxy, C1-C6 alkyl, nitro, hydroxyl, cyano, and amino;
- and
- B is selected from the group consisting of oxygen atom, nitrogen atom, carbon atom, sulfur atom, and NH.
Dependencies are inferred from the claim text.