Compound for inhibiting pge2/ep4 signaling transduction inhibiting, preparation method therefor, and medical uses thereof

A compound of formula (I):

• or a tautomer, mesomer, racemate, enantiomer, diastereomer thereof, or mixture thereof, or a pharmaceutically acceptable salt thereof,
• wherein:
• M1, M2, M3, M4, M5, M6 and M7 are each independently an N atom or C—R4;
• M4 is selected from the group consisting of N atom and C atom;
• ring A is selected from the group consisting of C6-10 aryl, C3-6 cycloalkyl, 5 to 10 membered heteroaryl and 3 to 6 membered heterocyclyl;
• X is
• Y is selected from the group consisting of a bond, C1-4 alkylene, —CR5R6—, —O—, —OC1-4 alkylene-, —NR9C1-4 alkylene- and —NR9—, wherein the C1-4 alkylene is optionally substituted by one or more substituents selected from the group consisting of H atom, D atom, halogen, hydroxy, cyano, amino, nitro, C1-4 alkyl, C1-4 alkoxy, haloC1-4 alkyl, haloC1-4 alkoxy, hydroxyC1-4 alkyl, C3-6 cycloalkyl, 3 to 6 membered heterocyclyl, C6-10 aryl and 5 to 10 membered heteroaryl;
• R1 and R2 are identical or different and are each independently selected from the group consisting of H atom, D atom, cyano, C1-4 alkyl, C1-4 alkoxy, C3-6 cycloalkyl, 3 to 6 membered heterocyclyl, —C(O)OR4, C(O)NR7R8, —COR4, —S(O)mR4, —NR7R8, C6-10 aryl and 5 to 10 membered heteroaryl, wherein the C1-4 alkyl and C1-4 alkoxy are each independently optionally substituted by one or more substituents selected from the group consisting of H atom, D atom, halogen, hydroxy, cyano, amino, nitro, C1-4 alkyl, C1-4 alkoxy, haloC1-4 alkyl, haloC1-4 alkoxy, hydroxyC1-4 alkyl, C3-6 cycloalkyl, 3 to 6 membered heterocyclyl, —C(O)OR4, C(O)NR7R8, —COR4, —NR4C(O)NR7R8, —OC(O)NR7R8, —NR7C(O)OR4, —S(O)mR4, —NR7R8, C6-10 aryl and 5 to 10 membered heteroaryl;
• or, R1 and R2 together with the atom to which they are attached form a C3-6 cycloalkyl or 3 to 6 membered heterocyclyl, wherein the C3-6 cycloalkyl and 3 to 6 membered heterocyclyl are each independently optionally substituted by one or more substituents selected from the group consisting of D atom, halogen, hydroxy, cyano, amino, nitro, —C(O)OR4, C(O)NR7R8, —COR4, —NR4C(O)NR7R8, —OC(O)NR7R8, —NR7C(O)OR4, —S(O)mR4, —NR7R8, C1-4 alkyl, C1-4 alkoxy, haloC1-4 alkyl, haloC1-4 alkoxy, hydroxyC1-4 alkyl, C3-6 cycloalkyl, 3 to 6 membered heterocyclyl, C6-10 aryl and 5 to 10 membered heteroaryl;
• each R3 is identical or different and each is independently selected from the group consisting of H atom, D atom, halogen, hydroxy, cyano, amino, nitro, C1-4 alkyl, C1-4 alkoxy, C3-6 cycloalkyl, 3 to 6 membered heterocyclyl, C6-10 aryl, 5 to 10 membered heteroaryl, —C(O)R4, —C(O)OR4, —OC(O)NR7R8, —NR7C(O)OR4, —S(O)mR4, —NR7R8 and —C(O)NR7R8, wherein the C1-4 alkyl, C1-4 alkoxy, C3-6 cycloalkyl, 3 to 6 membered heterocyclyl, C6-10 aryl and 5 to 10 membered heteroaryl are each independently optionally substituted by one or more substituents selected from the group consisting of C1-4 alkyl, hydroxyC1-4 alkyl, C1-4 alkoxy, haloC1-4 alkyl, haloC1-4 alkoxy, halogen, hydroxy, cyano, amino and nitro;
• R4 is selected from the group consisting of H atom, D atom, halogen, hydroxy, amino, C1-4 alkyl, C1-4 alkoxy, C3-6 cycloalkyl, 3 to 6 membered heterocyclyl, C6-10 aryl and 5 to 10 membered heteroaryl, wherein the C1-4 alkyl, C1-4 alkoxy, C3-6 cycloalkyl, 3 to 6 membered heterocyclyl, C6-10 aryl and 5 to 10 membered heteroaryl are each independently optionally substituted by one or more substituents selected from the group consisting of C1-4 alkyl, hydroxyC1-4 alkyl, C1-4 alkoxy, haloC1-4 alkyl, haloC1-4 alkoxy, halogen, hydroxy, cyano, amino and nitro;
• R5 and R6 are each independently selected from the group consisting of H atom, D atom, C1-4 alkyl, C3-6 cycloalkyl, 3 to 6 membered heterocyclyl, C6-10 aryl and 5 to 10 membered heteroaryl, wherein the C1-4 alkyl, C3-6 cycloalkyl, 3 to 6 membered heterocyclyl, C6-10 aryl and 5 to 10 membered heteroaryl are each independently optionally substituted by one or more substituents selected from the group consisting of C1-4 alkyl, hydroxyC1-4 alkyl, C1-4 alkoxy, haloC1-4 alkyl, haloC1-4 alkoxy, halogen, hydroxy, cyano, amino and nitro;
• or, R5 and R6 together with the atom to which they are attached form a C3-6 cycloalkyl or 3 to 6 membered heterocyclyl, wherein the C3-6 cycloalkyl and 3 to 6 membered heterocyclyl are each independently optionally substituted by one or more substituents selected from the group consisting of halogen, hydroxy, cyano, amino, nitro, C1-4 alkyl, C1-4 alkoxy, haloC1-4 alkyl, haloC1-4 alkoxy, hydroxyC1-4 alkyl, C3-6 cycloalkyl, 3 to 6 membered heterocyclyl, C6-10 aryl and 5 to 10 membered heteroaryl;
• R7 and R8 are each independently selected from the group consisting of H atom, D atom, C1-4 alkyl, haloC1-4 alkyl, C3-6 cycloalkyl, 3 to 6 membered heterocyclyl, C6-10 aryl and 5 to 10 membered heteroaryl, wherein the C1-4 alkyl, haloC1-4 alkyl, C3-6 cycloalkyl, 3 to 6 membered heterocyclyl, C6-10 aryl and 5 to 10 membered heteroaryl are each independently optionally substituted by one or more substituents selected from the group consisting of C1-4 alkyl, hydroxyC1-4 alkyl, C1-4 alkoxy, haloC1-4 alkyl, haloC1-4 alkoxy, halogen, hydroxy, cyano, amino and nitro;
• R9 is selected from the group consisting of H atom, D atom and C1-4 alkyl, wherein the C1-4 alkyl is optionally substituted by one or more substituents selected from the group consisting of hydroxyC1-4 alkyl, C1-4 alkoxy, haloC1-4 alkyl, haloC1-4 alkoxy, halogen, hydroxy, cyano, amino and nitro;
• m is 0, 1 or 2;
• and
• n is 0, 1, 2, 3 or 4.