A method for directly constructing highly optically active tetrasubstituted allenic acid compounds

The method for directly constructing highly optically active axially chiral allenic acid compounds, wherein, in the presence of palladium catalyst, chiral diphosphine ligand, monophosphine ligand and organic phosphoric acid, the tertiary propargyl alcohol with different substituents, carbon monoxide and water undergo asymmetric allylation reaction in an organic solvent through transition metal catalysis, constructing highly optically active axially chiral tetrasubstituted allenic acid compounds in one-step synthesis, the reaction process has the following reaction equation (I):

• reaction equation (I),
• wherein, R1 is an alkyl, an alkyl with functional group, phenyl, aryl or heterocyclic group;
• R2 is an alkyl, an alkyl with functional group, phenyl, aryl or heterocyclic group;
• R3 is an alkyl, an alkyl with functional group, phenyl, aryl or heterocyclic group;
• the said aryl is a phenyl with electron-donating or electron-withdrawing substituents at the ortho, meta, and para positions;
• the said heterocyclic group is thienyl, furyl, naphthyl or pyridyl, or thiophene, furan, naphthalene or pyridine with electron-donating or electron-withdrawing substituents.