Method for producing 1,2-alkane diols in a solid dosage form
AssigneeSymrise AG
InventorsJürgen SIEWERT, Torsten STEPHAN
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Abstract
A process is proposed for producing 1,2-alkanediols in a solid dosing form, comprising or consisting of the following steps: (a) providing a melt of at least one 1,2-alkanediol; (b) cooling the melt from step (a) to a temperature below the melting point of the 1,2-alkanediol or of the 1,2-alkanediol mixture to obtain a prescratched melt consisting of a supercooled 1,2-alkanediol or a supercooled 1,2-alkanediol mixture having a content of 1,2-alkanediol seed crystals; (c) contacting the mixture from step (b) with a cooled surface to obtain 1,2-alkanediols or 1,2-alkanediol mixtures in crystalline form.
Claims17
A process for producing 1,2-alkanediols in a solid dosing form, comprising the following steps:
- (a) providing a melt of at least one 1,2-alkanediol;
- (b) cooling the melt from step (a) to a temperature below the melting point of the 1,2-alkanediol or of the 1,2-alkanediol mixture to obtain a prescratched melt consisting of a supercooled 1,2-alkanediol or a supercooled 1,2-alkanediol mixture having a content of 1,2-alkanediol seed crystals;
- (c) contacting the mixture from step (b) with a cooled surface to obtain 1,2-alkanediols or 1,2-alkanediol mixtures in crystalline form.
Decane-1,2-diol in pelletized form, obtained by a process comprising:
- (a) melting decane-1,2-diol at about 60° C.,
- (b) gradually cooling the melt from step (a) to about 40 to 43° C., with stirring, until seed crystals separate out from the melt and the melt has reached a torque/viscosity of about 8 to about 12 Ncm,
- (c) dropletizing the prescratched melt from step (b) onto a precooled surface having a temperature within a range of from about 18 to about 20° C., and
- (d) removing the pellets thus obtained from the precooled surface after a solidification time of from about 1 to about 5 minutes.
Dodecane-1,2-diol in pelletized form, obtained by a process comprising:
- (a) melting dodecane-1,2-diol at about 60° C.,
- (b) gradually cooling the melt from step (a) to about 50 to 52° C., with stirring, until seed crystals separate out from the melt and the melt has reached a torque/viscosity of about 8 to about 12 Ncm,
- (c) dropletizing the prescratched melt from step (b) onto a precooled surface having a temperature within a range of from about 18 to about 20° C., and
- (d) removing the pellets thus obtained from the precooled surface after a solidification time of from about 1 to about 5 minutes.
Tetradecane-1,2-diol in pelletized form, obtained by a process comprising:
- (a) melting tetradecane-1,2-diol at about 80° C.,
- (b) gradually cooling the melt from step (a) to about 61 to 63° C., with stirring, until seed crystals separate out from the melt and the melt has reached a torque/viscosity of about 8 to about 12 Ncm,
- (c) dropletizing the prescratched melt from step (b) onto a precooled surface having a temperature within a range of from about 18 to about 20° C., and
- (d) removing the pellets thus obtained from the precooled surface after a solidification time of from about 1 to about 5 minutes.
Dependencies are inferred from the claim text.