Apparatus and methods for restoring tissue

A method of tissue restoration in a blood vessel of a subject comprising:

• providing a catheter into the blood vessel, the catheter comprising:
• a catheter shaft extending from a proximal end to a distal tip;
• a plurality of serial balloons positioned on a translucent distal segment of the catheter shaft proximal to the distal tip and positioned inside of and concentric with a distal balloon, the plurality of serial balloons in fluid communication with an inflation source via a first lumen, each of the plurality of serial balloons having a selectively expandable outermost radial surface and each of the plurality of serial balloons comprising:
• a translucent material;
• a series of isolated volumetric regions positioned between the plurality of serial balloons and recessed from the outermost radial surfaces of the serial balloons;
• a plurality of infusion ports, each infusion port is positioned between the plurality of serial balloons
• a distal balloon positioned around the plurality of serial balloons, the distal balloon comprises a plurality of apertures radially aligned with the isolated volumetric regions of the first distal balloon;
• and
• a light fiber positioned in the catheter shaft and extending through the translucent distal segment;
• supplying a drug from the drug source to the infusion ports;
• delivering the drug to the treatment area through the plurality of apertures;
• activating the light fiber thereby providing light transmission through the distal segment, the plurality of serial balloons, and the distal balloon to activate the drug in the treatment area.

An apparatus comprising

• a catheter shaft extending from a proximal end to a distal tip;
• a plurality of serial balloons positioned on a translucent distal segment of the catheter shaft proximal to the distal tip and positioned inside of and concentric with a distal balloon, the plurality of serial balloons in fluid communication with an inflation source via a first lumen, each of the plurality of serial balloons having a selectively expandable outermost radial surface and each of the plurality of serial balloons comprising:
• a translucent material;
• a series of isolated volumetric regions positioned between the plurality of serial balloons and recessed from the outermost radial surfaces of the serial balloons;
• a second distal balloon positioned around the plurality of serial balloons;
• and
• a light fiber positioned in the catheter shaft and extending through the translucent distal segment;
• wherein the drug source is configured to provide at least one drug to the distal balloon via the first lumen and during inflation of the plurality of serial balloons, the fluid fills between an inside surface of the distal balloon and inflation ports, gradually fills the isolated volumetric regions.