Cannabinoid composition and method of sublingual, buccal and oral mucosa delivery

A unit dose sublingual composition, comprising:

• (a) an extract of a cannabinoid containing Cannabis plant material, said extract comprising (i) one or more cannabinoid active agent(s) or (ii) a combination of said extract and one or more additional cannabinoid active agent(s), said additional cannabinoid active agent(s) selected from the group consisting of partially or completely purified cannabinoid compounds, synthetic cannabinoid compounds, and mixtures thereof;
• (b) an amount per unit dose of pregelatinized tapioca starch, wherein the amount of pregelatinized tapioca starch is 0.25 mg-2.0 mg per unit dose;
• and
• (c) an amount per unit dose of bromelain, wherein the amount of bromelain per unit dose is 0.05 mg-3.0 mg.

A method of manufacturing a unit dose sublingual composition, comprising:

• (a) adding an extract of a cannabinoid containing Cannabis plant material, an amount of pregelatinized tapioca starch, and an amount of bromelain into a blender or tumbler;
• (b) blending the ingredients together, thereby producing blended ingredients;
• and
• (c) compressing the blended ingredients using a tablet press;
• wherein the sublingual composition is a tablet for sublingual administration to a subject.

A method for reducing anxiety in a subject in need thereof, comprising administering to the subject a sublingual composition comprising:

• (a) an extract of a cannabinoid containing Cannabis plant material comprising (i) one or more cannabinoid active agent(s) or (ii) a combination of said extract and one or more additional cannabinoid active agent(s), said additional cannabinoid active agent(s) selected from the group consisting of partially or completely purified cannabinoid compounds, synthetic cannabinoid compounds, and mixtures thereof,
• (b) pregelatinized tapioca starch;
• and
• (c) bromelain;
• wherein the sublingual composition is placed underneath the tongue of the subject.