Cell
AssigneeAutolus Limited
InventorsPaul Smith, Martin Pulé, Simon Thomas, Isaac Gannon
Life of this patent
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Abstract
The present invention provides an engineered cell, such as a T-cell, which expresses a chimeric antigen receptor (CAR) or an engineered T-cell receptor (TCR) and one or more enzymes which, when secreted or expressed at the cell surface causes depletion of a molecule extracellular to the engineered cell; wherein said molecule is selected from: an amino acid; a nucleotide or nucleoside; or a lipid.
Claims28
A cell which expresses a chimeric antigen receptor (CAR) or engineered cell receptor (TCR) and one or more enzymes which, when secreted or expressed at the cell surface, causes depletion of a molecule extracellular to the cell,
- wherein said molecule is selected from:
- an amino acid, a nucleotide or nucleoside or a lipid.
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A nucleic acid construct which comprises:
- (i) a first polynucleotide which encodes an enzyme which, when secreted or expressed by a cell, causes depletion of a molecule extracellular to the cell,
- wherein said molecule is selected from:
- an amino acid, a nucleotide or nucleoside, or a lipid;
- and
- (ii) a second polynucleotide which encodes a chimeric antigen receptor (CAR) or a transgenic T-cell receptor (TCR).
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Dependencies are inferred from the claim text.