Method for adjusting a cell concentration and/or a particle concentration in a dispensing system
OwnerJonas SCHÖNDUBE, Lena LAUTSCHAM +1inventors
InventorsJonas SCHÖNDUBE, Lena LAUTSCHAM, Clara SIBER
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Abstract
The invention relates to a method for setting a cell concentration and/or a particle concentration in a dispensing device by means of which a liquid sample can be discharged, wherein the cell concentration and/or the particle concentration is ascertained in one region of the dispensing device, and the cell concentration and/or particle concentration that has been ascertained is compared with a target value, and a force exerted on one cell and/or one particle is adjusted based on the result of the comparison.
Claims43
A method for setting a cell concentration and/or a particle concentration in a dispensing device (1) by means of which a liquid sample (20) can be discharged, the method comprising:
- ascertaining the cell concentration and/or the particle concentration in the liquid sample;
- comparing the cell concentration and/or particle concentration that has been ascertained with a target value;
- and
- adjusting a force exerted on one cell and/or one particle based on a result of the comparison.
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A dispensing apparatus (6) comprising:
- a dispensing device (1) including a fluid chamber (5) into which a liquid sample (20) is introduced and a discharge channel (3) fluidically connected to the fluid chamber (5) through which the liquid sample (20) is discharged from the dispensing device (1), wherein the liquid sample (21) includes a liquid (2) and cells (4) and/or particles;
- a sound generator (7) arranged in association with the dispensing device (1), the sound generator being operable to generate an acoustic field;
- an actuating means (8) for actuating the dispensing device (1) to cause the dispensing device (1) to discharge a volume of the liquid sample (20) from the dispensing device (1);
- an evaluation device (12) configured to ascertain a cell concentration and/or particle concentration in the dispensing device (1);
- and
- a control apparatus (9) connected to the dispensing device (1), the sound generator (7), the actuating means (8), and the evaluation device (12);
- wherein the control apparatus (9) is configured to compare the ascertained cell concentration and/or particle concentration with a target value to provide a comparison result, and configured to adjust the cell concentration and/or particle concentration in the dispensing device (1) by adjusting a force exerted on a cell (4) and/or a particle in the liquid sample (20) as a function of the comparison result.
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Dependencies are inferred from the claim text.