Image-guided radiation treatment with imaging data using imaging radiation at different energy levels

A system, comprising:

• a radiation source;
• a processor, operatively coupled with the radiation source, to:
• process a first and second sets of image data to generate a combined image, wherein the combined image comprises a combination of the first and second sets of image data, wherein part or all of the image data comprises a target of a patient;
• register the combined image with another image to obtain a registration result;
• track the target using the registration result to generate tracking information;
• and
• direct treatment delivery to the target based on the tracking information obtained from the enhanced image.

A non-transitory machine readable medium that, when executed by a processor, causes the processor to:

• process a first and second sets of image data to generate an enhanced image, wherein the enhanced image comprises a combination of the first and second sets of image data, wherein part or all of the image data comprises a target of a patient;
• register the enhanced image with another image to obtain a registration result;
• track the target using the registration result to generate tracking information;
• and
• direct treatment delivery to the target based on the tracking information obtained from the enhanced image.