Bidirectional spike-timing-dependent brain network gain control
AssigneeMayo Foundation for Medical Education and Research
InventorsAnders J. Asp, Jose Luis L. Lujan
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Abstract
In an example method for increasing synaptic gain in a region of a brain of a subject, a first electromagnetic pulse is applied to a first neural element of a first neuron of the subject using a first electrode. The first neural element includes a first synapse coupled to a second neuron of the subject. Subsequent to applying the first electromagnetic pulse to the first neural element, a second electromagnetic pulse is applied to a second neural element of the second neuron using a second electrode.
Claims20
A method for increasing synaptic gain in a region of a brain of a subject, the method comprising:
- applying, using a first electrode, a first electromagnetic pulse to a first neural element of a first neuron of the subject, wherein the first neural element comprises a first synapse coupled to a second neuron of the subject;
- and
- subsequent to applying the first electromagnetic pulse to the first neural element, applying, using a second electrode, a second electromagnetic pulse to a second neural element of the second neuron.
A method for decreasing synaptic gain in a region of a brain of a subject, the method comprising:
- applying, using a first electrode, a first electromagnetic pulse to a first neural element of a first neuron of the subject, wherein the first neural element comprises a first synapse coupled to a second neuron of the subject;
- and
- subsequent to applying the first electromagnetic pulse to the first neural element, applying, using a second electrode, a second electromagnetic pulse to a second neural element of a third neuron, wherein the second neural element comprises a second synapse coupled to the first neuron.
Dependencies are inferred from the claim text.