Implantable neurostimulation system

An implantable neurostimulation system, comprising:

• at least one neural interface device for stimulating and/or inhibiting neural activity in a nerve such as the cervical vagus nerve, the at least one neural interface device comprising:
• first and second electrodes;
• at least one signal generator electrically coupled to the first and second electrodes and configured to generate first and second electrical signals that stimulate and/or inhibit neural activity in the nerve with the first and second electrical signals via the first and second electrodes, respectively;
• wherein the first electrical signal is configured to stimulate neural activity in the nerve to cause at least one pre-determined physiological response;
• and
• wherein the second electrical signal is configured to inhibit neural activity in the nerve to at least partially, optionally fully, suppress the least one pre-determined physiological response;
• the implantable neurostimulation system further comprising:
• at least one physiological sensor to detect the at least one pre-determined physiological response;
• and
• a control system communicatively coupled to the at least one physiological sensor and configured to generate a feedback response, upon receiving a signal from at least one physiological sensor.