Method and system for controlling molecular electrotransfer

Abstract

A system and method of controlling electrotransfer delivery of therapeutic molecules to targeted groups of cells. The system has an array of two or more physically contiguous electrodes configured to be inserted into biological tissue and a pulse generator configured to selectively drive the two or more electrodes as one or more anodes and one or more cathodes for application of electrical pulses. The physical configuration of the electrodes, selection of electrodes and anodes and cathodes, and applied electrical pulse parameters, control contours of gradients within the electric field for the target treatment region adjacent the array. A first selection of electrodes to drive as anodes and cathodes using one or more electric pulses is determined, and or the selected electrodes, electrical pulse parameters for one or more electric pulses to generate a first shaped electric field for a target treatment region adjacent the array are determined. A second selection of electrodes to drive as anodes and cathodes using one or more electric pulses is determined, and for the selected electrodes, electrical pulse parameters are determined for the one or more electric pulses to generate a second shaped electric field for a target treatment region adjacent the array. The pulse generator is controlled to apply a first sequence of one or more unipolar pulses using the first selection of electrodes driven as anodes and cathodes to generate a first shaped electric field, and a second sequence of one or more unipolar pulses using the second selection of electrodes driven as anodes and cathodes to provide a second shaped electric field.

Dependencies are inferred from the claim text.