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US 2022/0054727 A1Published application
System and method for removal of immune inhibitors from biological fluids
AssigneeImmunicom, Inc.
InventorsSteven JOSEPHS, Matthew ONG, Amir JAFRI, Robert SEGAL, Stephen PRINCE
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Abstract
The present system and method are useful for the removal of immune inhibitors such as soluble TNF receptors from the body fluid of cancer patients. In some embodiments, soluble TNF-Receptors 1 and 2 are selectively removed from plasma at 80% or more efficiency. In some embodiments, the system includes an immobilized capture ligand of a single chain TNFα. The system and method are useful for the treatment of different cancer types, stages and severity.
Claims15
1-41. (canceled)
A system for removing a target component from a body fluid of a patient, the system comprising:
- a housing;
- an inlet coupled to the housing and configured to receive the body fluid;
- a plurality of sequestering chambers disposed within the housing and configured to each receive a portion of the body fluid from the inlet;
- and
- an access port coupled to the housing and configured to facilitate insertion and/or removal of a capture support to or from one of the plurality of sequestering chambers.
2 more elements
Dependencies are inferred from the claim text.