System and method for removal of immune inhibitors from biological fluids
AssigneeImmunicom, Inc.
InventorsSteven JOSEPHS, Matthew ONG, Amir JAFRI, Robert SEGAL, Stephen PRINCE
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Abstract
The present system and method are useful for the removal of immune inhibitors such as soluble TNF receptors from the body fluid of cancer patients. In some embodiments, soluble TNF-Receptors 1 and 2 are selectively removed from plasma at 80% or more efficiency. In some embodiments, the system includes an immobilized capture ligand of a single chain TNFα. The system and method are useful for the treatment of different cancer types, stages and severity.
Claims16
1-41. (canceled)
A column for extracorporeal removal of a soluble tumor necrosis factor receptor (sTNF-R) from plasma of a patient, the column comprising:
- a compartment configured such that the plasma passes through the compartment;
- and
- a capture support disposed within the compartment;
- wherein the capture support has a leaching rate of less than 1670 ng/min.
Dependencies are inferred from the claim text.