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US 2022/0054724 A1Published application
System for continuous renal replacement therapy
AssigneeThe UAB Research Foundation
InventorsDavid ASKENAZI, Darryl INGRAM, Catherine S. GUROSCKY, Kara SHORT
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Abstract
Methods and systems for providing continuous renal replacement therapy (CRRT) to a patient are provided. The system includes a hemofiltration unit that provides continuous venovenous hemofiltration (CVVH), a replacement fluid flow regulator configured to regulate the flow of a replacement fluid, an anticoagulant flow regulator configured to pump an anticoagulant, and a blood warmer. The system provides enhanced access to the extracorporeal circuit for blood analysion, infusion of products and/or anticoagulation control. The system may be used to treat patients having renal insufficiency.
Claims51
A system for providing continuous renal replacement therapy to a patient in need thereof, the system comprising:
- (a) a hemofiltration unit comprising
- (i) a withdrawn blood line 120 connecting a hemofilter 140 to a first catheter connector;
- (ii) a blood pump 135 positioned to propel blood in the withdrawn blood line 120 from the first catheter connector to the hemofilter 140;
- (iii) a ultrafiltration line connected to receive a filtrate from the hemofilter 140;
- (iv) an ultrafiltration pump 175 configured to propel the filtrate from the ultrafiltration line by exerting negative pressure on the hemofilter 140;
- (v) a return line connected to receive a retentate from the hemofilter 140 and terminating in a second catheter connector;
- (vi) a sampling port in the return line;
- (vii) a sampling port in the withdrawn blood line 120;
- and
- (viii) an infusion fitting in the return line;
- (b) an anticoagulant flow regulator 130 configured to regulate the flow of anticoagulant from an anticoagulant source 125 into the withdrawn blood line 120;
- (c) a replacement fluid flow regulator 150 configured to regulate the flow of a replacement fluid from a replacement fluid source 155 into at least one of the withdrawn blood line and the return line;
- and
- (d) a blood warmer positioned to warm the retentate prior to infusion into the patient.
11 more elements
A system for providing continuous renal replacement therapy to a patient in need thereof, the system comprising:
- (a) a hemofiltration unit comprising
- (i) a withdrawn blood line 120 connecting a hemofilter 140 to a first catheter connector;
- (ii) a blood pump 135 positioned to propel blood in the withdrawn blood line 120 from the first catheter connector to the hemofilter 140;
- (iii) an ultrafiltration line connected to receive a filtrate from the hemofilter 140;
- (iv) an ultrafiltration pump 175 configured to propel the filtrate from the ultrafiltration line by exerting negative pressure on the hemofilter 140;
- (v) a return line connected to receive a retentate from the hemofilter 140 and terminating in a second catheter connector;
- (vi) a sampling port in the return line;
- (vii) a first access connector engaged to the first catheter connector and comprising a first infusion fitting and a first blood draw hub;
- and
- (viii) a second access connector engaged to the second catheter connector and comprising a second infusion fitting and a second blood draw hub;
- (b) an anticoagulant flow regulator 130 configured to regulate the flow of anticoagulant from an anticoagulant source 125 into the withdrawn blood line 120;
- (c) a replacement fluid flow regulator 150 configured to regulate the flow of a replacement fluid from a replacement fluid source 155 into at least one of the withdrawn blood line and the return line;
- and
- (d) a blood warmer positioned to warm the retentate prior to infusion into the patient.
11 more elements
A system for providing continuous renal replacement therapy to a patient in need thereof, the system comprising:
- (a) a hemofiltration unit comprising
- (i) a withdrawn blood line 120 connecting a hemofilter 140 to a first catheter connector;
- (ii) a blood pump 135 positioned to propel blood in the withdrawn blood line 120 from the first catheter connector to the hemofilter 140;
- (iii) an ultrafiltration line connected to receive a filtrate from the hemofilter 140;
- (iv) an ultrafiltration pump 175 configured to propel the filtrate from the ultrafiltration line by exerting negative pressure on the hemofilter 140;
- (v) a return line connected to receive a retentate from the hemofilter 140 and terminating in a second catheter connector;
- and
- (vi) a sampling port in the return line;
- (b) an anticoagulant flow regulator 130 configured to regulate the flow of anticoagulant from an anticoagulant source 125 into the withdrawn blood line 120;
- (c) a replacement fluid flow regulator 150 configured to regulate the flow of a replacement fluid from a replacement fluid source 155 into at least one of the withdrawn blood line and the return line;
- (d) a blood warmer positioned to warm the retentate prior to infusion into the patient;
- and
- (e) a blood analyzer connected to receive a blood sample from one of the withdrawn blood line 120 and the return line.
10 more elements
A system for providing continuous renal replacement therapy to a patient in need thereof, the system comprising:
- (a) a hemofiltration unit comprising
- (i) a withdrawn blood line 120 connecting a hemofilter 140 to a first catheter connector;
- (ii) a blood pump 135 positioned to propel blood in the withdrawn blood line 120 from the first catheter connector to the hemofilter 140;
- (iii) an ultrafiltration line connected to receive a filtrate from the hemofilter 140;
- (iv) an ultrafiltration pump 175 configured to propel the filtrate from the ultrafiltration line by exerting negative pressure on the hemofilter 140;
- (v) a return line connected to receive a retentate from the hemofilter 140 and terminating in a second catheter connector;
- and
- (vi) a sampling port in the return line;
- (b) an anticoagulant flow regulator 130 configured to regulate the flow of anticoagulant from an anticoagulant source 125 into the withdrawn blood line 120, said anticoagulant flow regulator 130 comprising an anticoagulant flow regulator control unit configured to control the rate of flow of anticoagulant from the anticoagulant source 125 into the withdrawn blood line 120;
- (c) a replacement fluid flow regulator 150 configured to regulate the flow of a replacement fluid from a replacement fluid source 155 into at least one of the withdrawn blood line and the return line;
- (d) a blood warmer positioned to warm the retentate prior to infusion into the patient;
- and
- (e) a coagulation analyzer connected to receive a blood sample from at least one of the withdrawn blood line 120 and the return line and configured to transmit measurements of coagulation to the anticoagulant flow regulator control unit.
10 more elements
The system of any one of the claims above, wherein the anticoagulant flow regulator 130 is a syringe pump.
Dependencies are inferred from the claim text.