Drug-delivering nerve wrap
AssigneeUniversity of Utah Research Foundation
InventorsBrett DAVIS, Jill SHEA, Himanshu SANT, Pratima LABROO, Bruce K GALE, Jayant P. AGARWAL
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Abstract
Described herein are medical film materials that incorporate one or more neuro-regenerative drugs into a polymer film. The polymer film includes a copolymer of lactide and caprolactone. The neuro-regenerative drug includes the macrolactam immunosuppressant FK506. The film is configured such that when placed under physiological conditions, the neuro-regenerative drug is released in an extended, substantially linear fashion for a period of at least 30 days.
Claims22
A medical film material, comprising:
- a polymer film comprising a copolymer of lactide and caprolactone;
- and
- a neuro-regenerative drug incorporated into the polymer film,
- wherein the polymer film is configured to provide substantially linear release of the neuro-regenerative drug over a period of at least 10 days when placed in a physiological environment.
(canceled)
A method of treating an injured nerve, comprising:
- providing a medical film material that includes
- a polymer film comprising a copolymer of lactide and caprolactone, and
- a neuro-regenerative drug incorporated into the polymer film,
- wherein the polymer film is configured to provide substantially linear release of the neuro-regenerative drug over a period of at least 10 days when placed in a physiological environment;
- and
- placing the medical film material at a nerve injury site.
(canceled)
A method of allotransplantation, comprising:
- providing a medical film material that includes
- a polymer film comprising a copolymer of lactide and caprolactone, and
- a neuro-regenerative drug incorporated into the polymer film,
- wherein the polymer film is configured to provide substantially linear release of the neuro-regenerative drug over a period of at least 10 days when placed in a physiological environment;
- and
- placing the medical film material into contact with allogenic tissue for transplantation.
Dependencies are inferred from the claim text.