Biodegradable functional polycarbonate nanoparticle carries for delivering molecular cargo
AssigneesInternational Business Machines Corporation, Agency for Science, Technology and Research
InventorsJames L. Hedrick, Nathaniel H. Park, Yi Yan Yang, Zhi Xiang Voo, Jeremy Tan
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Abstract
Techniques regarding the transportation of molecular cargo across the BBB are provided. For example, one or more embodiments described herein can comprise a chemical compound to facilitate molecular encapsulation of the molecular cargo. The chemical compound can comprise a diblock copolymer having a molecular backbone comprising a polycarbonate structure and a polyethylene glycol structure. Also, the polycarbonate structure can be functionalized with boronic acid.
Claims10
A method, comprising:
- conjugating a chemical compound to a copolymer via an acidity-sensitive covalent boronate ester bond, wherein the copolymer comprises a polycarbonate structure functionalized with boronic acid, and wherein the acidity-sensitive covalent boronate ester bond is formed between the boronic acid and a catechol moiety of the chemical compound.
A method, comprising:
- transporting a molecular cargo across a blood-brain-barrier via a molecular encapsulation of the molecular cargo within a nanoparticle and a biologically triggered release of the molecular cargo from the nanoparticle, wherein the molecular encapsulation is established by a boronate ester bond, and wherein the biologically triggered release is established by a change in acidity.
Dependencies are inferred from the claim text.